The three-fingered protein domain of the human genome

A Galat1

  • 1SIMOPRO, Bat 152, IBiTec/DSV/CEA, CE-Saclay, Gif-sur-Yvette Cedex, France. galat@dsvidf.cea.fr

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Overview
Chromatin Packaging02:21

Chromatin Packaging

Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.