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Neurotoxicological effects of a pyrethroid formulation, fenvalerate in rats
R Husain1, A Gupta, V K Khanna
1Industrial Toxicology Research Centre, Lucknow, India.
Research Communications in Chemical Pathology and Pharmacology
|July 1, 1991
Abstract:
The effect of systemic treatment of a synthetic pyrethroid insecticide, fenvalerate (FV) was examined in adult female rats at different doses i.e. 5, 10, 20 mg/kg body weight by gavage for 21 consecutive days on regional brain levels of noradrenaline (NA), dopamine (DA), their acid metabolites: dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) by HPLC-EC system. Our results demonstrate pronounced inhibition of NA, DA, HVA & DOPAC levels in several brain regions which were neither dose related nor region specific.