Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioplastics

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

Predicting Molecular Geometry

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries

Molecular Models

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.

Molecular Geometry and Dipole Moments

Molecular Geometry and Dipole Moments

The VSEPR theory can be used to determine the electron pair geometries and molecular structures as follows:

Plasticizers

Plasticizers

Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...

Microbial Bioremediation of Plastics

Microbial Bioremediation of Plastics

Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular and cellular characterization of Plasmodium berghei PPM9 phosphatase, an enzyme dispensable during both asexual and sexual life cycle stages.

Scientific reports·2026

Same author

Boscisucrophage: A Natural SGLT1/2 Inhibitor From <i>Boscia senegalensis</i> for Managing Type 2 Diabetes.

Food science & nutrition·2026

Same author

Characterization of the Regulatory AAA-ATPase Subunit Rpt3 in <i>Plasmodium berghei</i> as an Activator of Protein Phosphatase 1.

International journal of molecular sciences·2025

Same author

Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation.

Neurogastroenterology and motility·2025

Same author

Discovery of Potent Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Inhibitors with Antiferroptotic Properties.

Journal of medicinal chemistry·2025

Same author

LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode.

Angewandte Chemie (International ed. in English)·2025

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Published on: June 2, 2023

Molecular modelling of phthalates - PPARs interactions.

Nicolas Kambia¹, Nicolas Renault, Sebastien Dilly

¹Laboratoire de Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques, Lille Cedex, France.

Journal of Enzyme Inhibition and Medicinal Chemistry

|September 30, 2008

Summary

Di(2-ethylhexyl) phthalate (DEHP), a common PVC plasticizer, poses toxicity risks by activating PPAR(alpha). Tri(2-ethylhexyl) trimellitate (TOTM) shows promise as a safer alternative, as it does not bind to PPARs.

More Related Videos

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

Related Experiment Videos

Last Updated: Jun 30, 2026

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Published on: June 2, 2023

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

Area of Science:

Toxicology
Polymer Chemistry
Molecular Biology

Background:

Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer in PVC products, including medical devices and food packaging.
DEHP's toxicity is partly attributed to its activation of peroxisome proliferator-activated receptor alpha (PPAR(alpha)).
This has driven research into safer, biologically inert plasticizers like tri(2-ethylhexyl) trimellitate (TOTM).

Purpose of the Study:

To investigate the potential interaction of TOTM and DEHP with PPAR(alpha) and PPAR(gamma) binding sites.
To assess the safety profile of TOTM as a potential DEHP alternative.

Main Methods:

Molecular docking simulations were employed to predict the binding affinities of TOTM, DEHP, and DEHP metabolites to PPAR(alpha) and PPAR(gamma).

Main Results:

Docking results suggest that TOTM does not effectively bind to PPAR(alpha) or PPAR(gamma) binding sites.
DEHP and its metabolites showed potential for binding to these receptors.

Conclusions:

TOTM demonstrates a lower potential for PPAR activation compared to DEHP.
TOTM is a promising candidate for a safer plasticizer, warranting further biological evaluation.