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Updated: Jun 30, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Determination of (+)-3,3',5,5'-Tetraiodo-L-thyronine (L-T4) in Serum and pharmaceutical formulations using a
Raluca-Ioana Stefan-van Staden1, Jacobus Frederick van Staden, Hassan Y Aboul-Enein
1Laboratory of Electrochemistry Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania. iustinavanstaden@yahoo.com
Abstract:
A sequential injection analysis/immunosensor system is proposed for the analysis of thyroxine (L-T4) in serum and in pharmaceutical formulations with a rate of 75 samples/hour. The immunosensor design is based on the physical immobilization of anti-L-T4 in carbon paste. The working concentration range of the immunosensor in the sequential injection analysis system is between 36 and 1080 ng/mL with a limit of detection of 24.6 ng/mL. The system is very reliable and very easy to design and operate.
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