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Updated: Jun 30, 2026
The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Perfusion-weighted magnetic resonance imaging patterns of hypoxic-ischemic encephalopathy in term neonates
Pia Wintermark1, Adrien C Moessinger, François Gudinchet
1Division of Neonatology, Department of Pediatrics, Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. pia.wintermark@bluemail.ch
Purpose:
To determine whether an early magnetic resonance imaging (MRI) study using perfusion-weighted imaging (PWI) may define the pattern of brain injury in term neonatal hypoxic-ischemic (HI) encephalopathy.
Materials And Methods:
Five newborns with HI encephalopathy or a marker of perinatal depression, and 2 controls underwent an early MRI (at 2 to 4 days), including PWI. Relative cerebral blood flow (rCBF) values were measured.
Results:
On early (
Conclusion:
PWI is technically feasible in neonates with HI encephalopathy in a reproducible way, permitting comparisons between children. It provides a practical means to identify early after birth the future definitive ischemic areas that may be shown on conventional MRI only later.
