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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Published on: December 3, 2015

DNA nanotubes as combinatorial vehicles for cellular delivery.

SeungHyeon Ko¹, Haipeng Liu, Yi Chen

¹Purdue University, Department of Chemistry, West Lafayette, Indiana 47907, USA.

Biomacromolecules

|September 30, 2008

Summary

Self-assembled DNA nanotubes carrying cancer-targeting and imaging agents show effective cellular uptake in cancer cells. This novel drug delivery system demonstrates no obvious toxicity in preliminary experiments.

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Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

DNA nanostructures offer potential for advanced drug delivery systems.
Self-assembly of DNA into nanotubes provides a novel carrier platform.

Purpose of the Study:

To investigate the use of self-assembled DNA nanotubes as carriers for drug delivery.
To functionalize DNA nanotubes with targeting and imaging agents for cancer cell delivery.

Main Methods:

Conjugation of folate (targeting agent) and Cy3 (imaging agent) to DNA strands.
Self-assembly of functionalized DNA strands into micrometer-long nanotubes (NTs).
Assessment of cellular uptake in cancer cells using fluorescence imaging and fluorescence-activated cell sorting.

Main Results:

Functionalized DNA-NTs were successfully synthesized.
Effective cellular uptake of conjugated DNA-NTs by cancer cells was demonstrated.
No significant toxicity was observed under the experimental conditions.

Conclusions:

Self-assembled DNA nanotubes are a viable platform for targeted drug delivery.
Functionalized DNA-NTs show promise for cancer cell targeting and imaging.
The developed system exhibits a favorable safety profile in initial assessments.