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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Jun 30, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

[Prematurity and neonatal screening].

¹Association Française pour le Dépistage et la Prévention des Handicaps de l'Enfant (AFDPHE), Laboratoire de biochimie, Hôpital St Philibert, 115 rue du grand But, 59462 Lomme cedex, France. dhondt.jeanlouis@ghicl.net

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|November 26, 2008

Summary

This summary is machine-generated.

Neonatal screening for metabolic and endocrine diseases benefits full-term infants. However, prematurity complicates screening, increasing false results and necessitating strategy adjustments for preterm infants.

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Area of Science:

Neonatal medicine
Endocrinology
Metabolic disorders

Context:

Neonatal screening for metabolic and endocrine diseases is crucial for full-term infants.
Preterm infants present unique challenges in neonatal screening.
Prematurity increases the risk of false-positive and false-negative screening results.

Purpose:

To evaluate the impact of prematurity on neonatal screening strategies.
To determine if gestational age-specific cut-off values are needed for preterm infants.
To assess the necessity of repeat screening tests for preterm infants.

Summary:

Neonatal screening offers significant benefits for full-term infants through early diagnosis and treatment.
Preterm infants face a higher likelihood of inaccurate screening results (false positives/negatives).
This study investigates adjustments to screening protocols, including cut-off values and repeat testing, for preterm infants.

Impact:

Informing optimized neonatal screening protocols for preterm populations.
Improving the accuracy and reliability of newborn screening for vulnerable infants.
Guiding clinical decisions on adjusting screening parameters based on gestational age.