Related Experiment Videos
Clinical manifestations of hyperuricemia and gout
1Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH 44195, USA. mandelb@ccf.org
Abstract:
Biologically significant hyperuricemia occurs when serum urate levels exceed urate solubility, ie, at approximately 6.8 mg/dL. At serum urate levels above this threshold, manifestations of chronic crystal deposition, including gouty arthritis, may occur, although asymptomatic hyperuricemia often persists for many years without progression. Intercritical asymptomatic periods follow the resolution of acute gout flares, but crystals remain in the joint during these intervals and further deposition may continue silently. Ultimately this may lead to persistent attacks, chronic pain, and, in some patients, joint damage.
Related Concept Videos
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Chronic Kidney Disease II: Clinical Manifestations
Type I Diabetes III: Clinical Manifestations
Hyperthyroidism I: Introduction
Graves' Disease I: Introduction
Hyperglycemia