Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell surface antigens induced by herpes simplex virus (HSV).

R Gologan, G R Ghyka

    Virologie
    |July 1, 1976
    PubMed
    Summary

    Herpes simplex virus (HSV) infection induces surface antigens (HSV-Ag) and immunoglobulin receptors (IgR). HSV-1 strains characteristically induce IgR, unlike HSV-2, with implications for diagnostic methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effective teaching modifies medical student attitudes toward pain symptoms.

    European journal of trauma and emergency surgery : official publication of the European Trauma Society·2016
    Same author

    [Medical and sociodemographic aspects of domestic violence. Systematic evaluation of patient data from the emergency department of a maximum care hospital].

    Der Unfallchirurg·2013
    Same author

    [Carpal lesions associated with dislocated fractures of the distal radius. A systematic screening of 104 fractures using preoperative CT and MRI].

    Der Unfallchirurg·2012
    Same author

    Demo-geographical data of myelodysplastic syndrome based on a large sample of patients from a Romanian Hematological Center.

    Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2010
    Same author

    Laparoscopic splenectomy can induce significant improvement in hypoplastic myelodysplastic syndrome.

    Romanian journal of internal medicine = Revue roumaine de medecine interne·2007
    Same author

    Remission induction in elderly acute myeloid leukemia by low-dose melphalan.

    Romanian journal of internal medicine = Revue roumaine de medecine interne·2004

    Area of Science:

    • Virology
    • Immunology
    • Cell Biology

    Background:

    • Herpes simplex virus (HSV) infection leads to the expression of specific antigens on the surface of infected host cells.
    • These viral antigens play a crucial role in the host immune response and can be targets for diagnostic assays.
    • Understanding the nature and characteristics of these induced antigens is vital for developing effective detection methods.

    Purpose of the Study:

    • To differentiate and characterize two types of antigens induced by HSV on infected cell surfaces: HSV-antigens (HSV-Ag) and immunoglobulin receptors (IgR).
    • To investigate the differential induction of IgR by various HSV strains, particularly HSV-1 and HSV-2.
    • To explore the potential diagnostic implications of HSV-Ag and IgR for detecting HSV infection.

    Main Methods:

    • HSV-antigens (HSV-Ag) were detected using cytotoxicity assays and mixed agglutination tests.
    • Immunoglobulin receptors (IgR) were identified and visualized using passive hemadsorption techniques.
    • Comparative analysis of IgR induction was performed across different viral infections, including various HSV strains and other viruses.

    Main Results:

    • Two distinct types of antigens were identified on HSV-infected cells: HSV-Ag binding the Fab site of anti-HSV antibodies and IgR likely binding the Fc fragment.
    • The induction of IgR was found to be a characteristic feature of HSV-1 strains, with limited or absent expression in HSV-2 strains.
    • IgR were not detected on cells infected with other viruses, including poliovirus, adenovirus, measles, vaccinia, cytomegalovirus, pseudorabies, and bovine infectious rhinotracheitis virus (with minimal expression).

    Conclusions:

    • HSV-1 uniquely induces immunoglobulin receptors (IgR) on infected cell surfaces, distinguishing it from HSV-2 and other viral infections.
    • The presence of both HSV-Ag and strain-specific IgR has significant implications for the development and refinement of diagnostic techniques for HSV.
    • Further research into these viral surface markers can enhance the specificity and sensitivity of HSV detection assays.

    Related Experiment Videos