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Related Experiment Video

Updated: Jun 30, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Mannose-binding lectin gene polymorphisms in relation to periodontitis.

Anna Louropoulou1, Ubele van der Velden, Ton Schoenmaker

  • 1Department of Periodontology, Academic Centre for Dentistry Amsterdam, ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands. A.Louropoulou@acta.nl

Journal of Clinical Periodontology
|October 1, 2008
PubMed
Summary

Mannose-binding lectin (MBL) gene polymorphisms are not linked to periodontitis susceptibility. However, MBL functions as a weak acute-phase protein in periodontitis patients, with higher plasma levels observed in low-producing patients.

Related Experiment Videos

Last Updated: Jun 30, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

  • Immunogenetics
  • Oral Biology
  • Molecular Epidemiology

Background:

  • Mannose-binding lectin (MBL) plays a crucial role in the innate immune system.
  • MBL gene polymorphisms can influence MBL plasma levels and immune response.
  • Periodontitis is a common inflammatory disease affecting the supporting structures of teeth.

Purpose of the Study:

  • To investigate the association between MBL gene polymorphisms and periodontitis.
  • To determine the correlation between MBL genotypes and MBL plasma levels in periodontitis.
  • To explore the role of MBL as an acute-phase protein in periodontitis.

Main Methods:

  • Genotyping of six functional MBL gene polymorphisms (L/H, X/Y, P/Q, A/D, A/B, A/C) in 92 periodontitis patients and 70 controls.
  • Comparison of genotype frequencies, allele carriage rates, and allele frequencies between patients and controls.
  • Measurement and comparison of plasma MBL levels across different genotype groups.

Main Results:

  • No significant differences in MBL genotype frequencies were found between periodontitis patients and controls.
  • Subjects with high-producing MBL genotypes exhibited significantly higher plasma MBL levels compared to low-producers and deficient subjects (p<0.001).
  • Plasma MBL levels were significantly higher in low-producer periodontitis patients than in low-producer controls (p(adjusted)=0.021).

Conclusions:

  • MBL gene polymorphisms are not associated with periodontitis susceptibility in the studied Caucasian population.
  • Genotyping successfully differentiated MBL production phenotypes (high, low, deficient).
  • This study provides the first evidence that MBL acts as a weak acute-phase protein in the context of periodontitis.