Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hemodynamic responses to low-level transcutaneous auricular nerve stimulation in young volunteers.

IBRO neuroscience reports·2023
Same author

A model for potential non-contact ski injuries of the knee.

Sports medicine and health science·2022
Same author

Cardiovascular responses to low-level transcutaneous vagus nerve stimulation.

Autonomic neuroscience : basic & clinical·2021
Same author

Quadriceps strength asymmetry as predictor of ankle sprain in male volleyball players.

The Journal of sports medicine and physical fitness·2021
Same author

Framework for Personalized Real-Time Control of Hidden Temperature Variables in Therapeutic Knee Cooling.

IEEE journal of biomedical and health informatics·2020
Same author

Medical-Grade ECG Sensor for Long-Term Monitoring.

Sensors (Basel, Switzerland)·2020
Same journal

sEEGnal: an automated EEG preprocessing pipeline evaluated against expert-driven preprocessing.

Computers in biology and medicine·2026
Same journal

Corrigendum to "Integrating experimental biology, computational methods, and artificial Intelligence in anticancer drug discovery: Bridging the translational Gap" [Comput. Biol. Med. 213 (2026) 111832].

Computers in biology and medicine·2026
Same journal

Organ dose optimization for a point-of-care forearm X-ray photon-counting CT.

Computers in biology and medicine·2026
Same journal

Physics-guided transformation of breathomic feature spaces into disease-specific representations for respiratory disease classification.

Computers in biology and medicine·2026
Same journal

An AI-driven deep learning pipeline for taxonomic classification and biodiversity assessment of deep-sea environmental DNA.

Computers in biology and medicine·2026
Same journal

Rapid personalisation of cardiovascular models using invasively measured right ventricular pressure.

Computers in biology and medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2026

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

Computer simulation of topical knee cooling.

Roman Trobec1, Marjan Sterk, Said AlMawed

  • 1Department of Communication Systems, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.

Computers in Biology and Medicine
|October 1, 2008
PubMed
Summary
This summary is machine-generated.

Local cooling after knee injury or surgery can have varied effects. Computer simulations reveal how temperature changes in knee tissues over time, aiding understanding of topical cooling methods like cryo-cuffs and gel-packs.

More Related Videos

Experimental Methods for Investigation of Shape Memory Based Elastocaloric Cooling Processes and Model Validation
11:11

Experimental Methods for Investigation of Shape Memory Based Elastocaloric Cooling Processes and Model Validation

Published on: May 2, 2016

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
10:23

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jun 30, 2026

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

Experimental Methods for Investigation of Shape Memory Based Elastocaloric Cooling Processes and Model Validation
11:11

Experimental Methods for Investigation of Shape Memory Based Elastocaloric Cooling Processes and Model Validation

Published on: May 2, 2016

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
10:23

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Published on: December 1, 2023

Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Orthopedics

Background:

  • Topical cooling using gel-packs or cryo-cuffs is a common post-operative and post-injury treatment for knees.
  • While generally beneficial, reported deleterious effects necessitate a deeper understanding of cooling's impact on knee tissues.
  • The temporal and spatial distribution of temperature changes within the knee during cooling is not well-studied.

Purpose of the Study:

  • To non-invasively investigate the spatio-temporal temperature changes within the knee during topical cooling.
  • To simulate and analyze heat transfer dynamics in heterogeneous knee tissues.
  • To compare the thermal effects of cryo-cuff versus gel-pack cooling methods.

Main Methods:

  • Developed a 3-D finite element model of the human knee using the Visible Human Dataset.
  • Modeled heat transfer using a diffusion equation solved via the explicit finite difference method.
  • Incorporated heat transfer between blood and tissue, and simulated tissue metabolism.
  • Performed simulations for constant-temperature liquid cooling (cryo-cuff) and frozen gel-pack cooling.

Main Results:

  • Simulated temperature distributions within the knee under different cooling conditions.
  • Quantified the rate and depth of tissue cooling for both cryo-cuff and gel-pack methods.
  • Results were analyzed and compared with available experimental measurements.

Conclusions:

  • Computer simulation provides a valuable tool for understanding non-invasive thermal changes in the knee.
  • The study provides insights into the differential effects of various topical cooling modalities.
  • Findings can inform optimized application protocols for cryo-cuffs and gel-packs to enhance therapeutic outcomes.