Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Letter:</i> A Longitudinal Model of HIV Clinical Pharmacy Service Expansion: A Decade-Plus Model of Clinical Expansion and Practice Integration.

AIDS patient care and STDs·2026
Same author

Pregnancy Outcomes after Exposure to Tuberculosis Treatment in Phase 3 Clinical Trial, 2016-2020.

Emerging infectious diseases·2026
Same author

Monocyte Activation in People With HIV and Tuberculosis Coinfection and Effect of Tuberculosis Preventive Therapy: An Analysis of the ACTG A5279/BRIEF TB Trial.

Open forum infectious diseases·2026
Same author

Protecting households on exposure to newly diagnosed index multidrug-resistant tuberculosis patients: Study protocol for the PHOENIx phase 3 clinical trial.

Contemporary clinical trials·2025
Same author

Preventing Multidrug-Resistant Tuberculosis: The Dawn of a New Era.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Author Correction: Risk-stratified treatment for drug-susceptible pulmonary tuberculosis.

Nature communications·2025

Related Experiment Video

Updated: Jun 30, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Extensively drug-resistant tuberculosis.

Miguel G Madariaga1, Umesh G Lalloo, Susan Swindells

  • 1Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198-8106, USA. mmadariaga@unmc.edu

The American Journal of Medicine
|October 1, 2008
PubMed
Summary
This summary is machine-generated.

Extensively drug-resistant tuberculosis (XDR-TB) is a growing global threat requiring rapid diagnosis and challenging treatment. Early detection and improved public health infrastructure are crucial for managing this severe form of tuberculosis.

More Related Videos

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
08:10

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

Related Experiment Videos

Last Updated: Jun 30, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
08:10

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Extensively drug-resistant tuberculosis (XDR-TB) is defined by resistance to key anti-TB drugs.
  • XDR-TB, initially identified in South Africa, is now a global health concern, with cases reported worldwide.
  • Inadequate treatment and public health failures are primary drivers of XDR-TB emergence.

Purpose of the Study:

  • To highlight the global threat of extensively drug-resistant tuberculosis.
  • To emphasize the need for improved diagnostic capabilities and laboratory networks.
  • To discuss the challenges in treating XDR-TB and the importance of infection control.

Main Methods:

  • This study is a review of the current understanding of XDR-TB.
  • It synthesizes information on the definition, emergence, diagnosis, and treatment of XDR-TB.
  • It discusses the implications for public health and patient management.

Main Results:

  • XDR-TB poses a significant global challenge, necessitating urgent attention.
  • Accurate and rapid diagnostic tests are essential for identifying active cases.
  • Effective treatment regimens are complex and may involve surgery.

Conclusions:

  • Strengthening diagnostic networks and developing faster tests are critical for combating XDR-TB.
  • Managing XDR-TB requires a multi-faceted approach, including robust treatment strategies and stringent infection control.
  • Addressing underlying public health infrastructure issues is vital to curb the spread of drug-resistant tuberculosis.