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An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions
Published on: March 14, 2016
Non-classical hydrogen bonds in interleukins: the role of C-H...O interactions
Sudha Anand1, Anand Anbarasu, Rao Sethumadhavan
1Bioinformatics & Computational Biology Division, School of Biotechnology, Chemical & Biomedical Engineering, Vellore Institute of Technology, Thiruvalam Road, Vellore 632014, India.
Abstract:
The role of classical hydrogen bonds in the structural stability of biological macro-molecules is well understood. In the present study, we explore the influence of C-H...O interactions in relation to other environmental preferences in interleukins. Main chain-main chain interactions are predominant. Pro residues might stabilize helices and strands by C-H...O H-bonds in interleukins. Majority of the C-H...O interacting residues were solvent exposed. 62% of C-H...O interactions was long-range interactions. The results presented in this study might be useful for structural stability studies in interleukins.
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