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Updated: Jun 30, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Default-mode brain dysfunction in mental disorders: a systematic review.

Samantha J Broyd1, Charmaine Demanuele, Stefan Debener

  • 1Institute for Disorders of Impulse & Attention, Developmental Brain-Behaviour Laboratory, School of Psychology, University of Southampton, UK. s.broyd@soton.ac.uk

Neuroscience and Biobehavioral Reviews
|October 1, 2008
PubMed
Summary
This summary is machine-generated.

The default-mode network (DMN) plays a key role in mental disorders. DMN dysfunction is linked to conditions like dementia, schizophrenia, and ADHD, highlighting its importance in brain health.

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

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Related Experiment Videos

Last Updated: Jun 30, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • The default-mode network (DMN) is a large-scale brain network active during rest.
  • Its functional organization and cognitive roles are increasingly understood.
  • Abnormalities in DMN function are implicated in various mental health conditions.

Purpose of the Study:

  • To review the role of the DMN in the pathophysiology of mental disorders.
  • To explore mechanisms linking DMN abnormalities to specific psychiatric conditions.
  • To identify common and unique DMN-related features across diverse mental disorders.

Main Methods:

  • Systematic review of empirical literature.
  • Definition and conceptualization of the DMN, including its neuroanatomy and functional organization.
  • Analysis of proposed mechanisms connecting DMN dysfunction to mental disorders.

Main Results:

  • DMN dysfunction is associated with dementia, schizophrenia, epilepsy, anxiety, depression, autism, and ADHD.
  • Identified common and distinct patterns of DMN involvement across these disorders.
  • Highlighted interference during task performance and altered network connectivity as key mechanisms.

Conclusions:

  • The DMN is a critical network in understanding the neurobiology of mental disorders.
  • Further research is needed to elucidate specific DMN alterations and therapeutic targets.
  • Integrative approaches are essential for a comprehensive understanding of DMN dysfunction in psychopathology.