Related Experiment Video
Updated: Jun 30, 2026

Quantitative Analysis of Aspergillus nidulans Growth Rate using Live Microscopy and Open-Source Software
Published on: July 24, 2021
The CYPome (Cytochrome P450 complement) of Aspergillus nidulans
Diane E Kelly1, Nada Krasevec, Jonathan Mullins
1Institute of Life Sciences, 6 School of Medicine, Swansea University, Singleton Park, Swansea SA2, 8PP, UK. D.Kelly@swansea.ac.uk
Abstract:
The cytochromes P450 (CYPs) are found in all biological kingdoms and genome sequencing projects continue to reveal an ever increasing number. The principle aim of this paper is to identify the complete CYPome of Aspergillus nidulans from the genome sequence version AN.3 deposited at the Broad institute, assign the appropriate CYP nomenclature and define function where possible. The completed analysis revealed a total of 111 CYP genes, 3 of which were previously unknown and 8 pseudogenes, representing 89CYP families, 21 of which are unique. We have identified 28 potential gene clusters associated with one or more CYP genes and discussed those with putative PKS and NRPS associated function. The chromosomal location of the genes, predicted cellular location of the proteins and possible function(s) are discussed.
Related Concept Videos
Fungal Phylum Ascomycota
Allosteric Proteins-ATCase
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Antifungal Agents