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Intermittent versus continuous pantoprazole infusion in peptic ulcer bleeding: a prospective randomized study
Ilhami Yüksel1, Hilmi Ataseven, Seyfettin Köklü
1Department of Gastroenterology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey. yukselilhami@hotmail.com
Digestion
|October 1, 2008
Summary
Intermittent and continuous pantoprazole infusions show similar effectiveness in preventing peptic ulcer rebleeding after endoscopic therapy. Both methods offer comparable outcomes for hospital stay and transfusion needs, with intermittent dosing presenting practical advantages.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Peptic ulcer rebleeding is a major factor in poor patient prognosis.
- Gastric acid significantly contributes to the development of rebleeding.
- Endoscopic therapy is a primary treatment for peptic ulcer bleeding.
Purpose of the Study:
- To compare the efficacy of intermittent versus continuous pantoprazole infusion in preventing peptic ulcer rebleeding post-endoscopic therapy.
- To evaluate the impact of different pantoprazole administration methods on clinical outcomes.
Main Methods:
- Prospective randomized study involving patients with active peptic ulcer bleeding.
- Patients received initial endoscopic therapy followed by randomization to intermittent or continuous intravenous pantoprazole.
- Key outcomes measured included rebleeding rates, hospital stay duration, blood transfusion requirements, and urgent surgery rates.
Main Results:
- No significant differences were observed in rebleeding rates (6.1% vs. 8.3%) between intermittent and continuous pantoprazole groups.
- Hospital stay duration, need for blood transfusions, and rates of urgent surgery were comparable across both treatment arms.
- No bleeding-related deaths occurred in either group.
Conclusions:
- Both intermittent and continuous pantoprazole infusions are equally effective in reducing peptic ulcer rebleeding after successful endoscopic treatment.
- Clinical outcomes such as hospital stay and need for transfusion/surgery are similar for both administration methods.
- Intermittent pantoprazole administration offers advantages in terms of application and cost-effectiveness compared to continuous infusion.
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