Related Experiment Video

Updated: Jun 30, 2026

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

FXR: a metabolic regulator and cell protector

Yan-Dong Wang1, Wei-Dong Chen, David D Moore

  • 1Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.

Cell Research
|October 1, 2008
PubMed

Insights

Farnesoid X receptor (FXR) regulates metabolism and has newly discovered roles in gut health and liver disease. These findings highlight FXR as a promising therapeutic target for various conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Farnesoid X receptor (FXR) is a nuclear receptor controlling bile acid, lipid, and glucose metabolism.
  • FXR is implicated in metabolic syndrome and related disorders.
  • FXR is a validated drug target for metabolic diseases.

Purpose of the Study:

  • To review the established metabolic regulatory functions of FXR.
  • To highlight recently discovered non-metabolic roles of FXR.
  • To underscore FXR's expanded therapeutic potential.

Main Methods:

  • Literature review of FXR research.
  • Analysis of studies on FXR's role in metabolism.
  • Examination of emerging research on FXR's broader functions.

Main Results:

  • FXR is a central regulator of bile acid homeostasis and lipid metabolism.
  • Emerging evidence shows FXR influences intestinal antibacterial defense.
  • FXR plays significant roles in liver regeneration and hepatocarcinogenesis.

Conclusions:

  • FXR's functions extend beyond metabolic regulation.
  • FXR is a versatile therapeutic target for metabolic and other diseases.
  • Further research into FXR's diverse roles is warranted.

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