[Pathogenetic principles of the diagnosis of chronic inflammation]

The main attention in diagnosis of chronic exudative-destructive inflammation resulting from tissue injury should be focused on responsiveness and functional reserves of polymorphonuclear leukocytes (PML) from blood and lesion, the key effectors of inflammatory reaction. The ability of phagocytes to migrate into the lesion site and generate phlogogenic substances is to be analysed. Basing on the initial state of PML system and its functional limits one can predict the effectiveness of the treatment with antiinflammatory drugs and immunostimulators. In the diagnosis of mononuclear infiltrative inflammation the reliable assessment of macrophage responsiveness and their relations with lymphoid cells is of great importance.