[Cyclic nucleotides, prostaglandins and thrombocyte aggregation in rats poisoned with "murine" Yersinia pestis toxin]

Y. pestis "mouse" toxin, introduced intraperitoneally into rats in a dose of LD100 [correction of LG100], produces phasic changes in the thrombin-induced aggregation of thrombocytes and the content of prostaglandins and cyclic nucleotides in them. As the result of the damaging action on the endothelium of blood vessels at the initial period of intoxication, the concentration of prostaglandin 6-keto F1 alpha in blood plasma and cAMP [correction of cAMR] in thrombocytes sharply decreases, which causes the enhancement of thrombin-induced cell aggregation. At a later period the level of prostaglandin E in the cells sharply rises. At later irreversible stages of shock, induced in the cells of Y. pestis "mouse" toxin, the content of cGMP in cells sharply increases, which leads to the development of the phase of thrombocyte hypoaggregation.