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Sixth mycelial fraction acetone (6-MFA), an interferon inducer modulates acrylamide neurotoxicity
R Husain1, V K Khanna, S I Zaidi
1Industrial Toxicology Research Centre, Lucknow, India.
Abstract:
A single i.p. administration of an immunomodulatory agent 6-MFA (a biological response modifier and antiviral agent of fungal origin, 10 mg/100g b.wt.), on 5th day of repeated acrylamide (ACR, 50 mg/kg b.wt.) treatment significantly protected rats against its specific neurotoxic effects. Corpus striatal 3H-spiperone binding elevated (24%) while glutathione-S-transferase (GST) activity decreased (33%) in ACR group but values were markedly restored in 6-MFA alone and co-exposed group. Development of hind limb paralysis was also protected by 6-MFA. Results warrant the possible involvement of immune mechanisms and certain other factors such as lymphokines, hormones and microglia at the target site, which in turn facilitate the repair mechanism suggesting a therapeutic role of 6-MFA in clinical cases of toxic neuropathies in future.
Insights
The immunomodulatory agent 6-MFA protected rats from acrylamide neurotoxicity by restoring biochemical markers and preventing paralysis. This suggests 6-MFA
Area of Science:
- Neuroscience
- Immunology
- Toxicology
Background:
- Acrylamide (ACR) is a neurotoxin causing specific neurological deficits.
- Understanding protective mechanisms against ACR-induced neurotoxicity is crucial.
Purpose of the Study:
- To investigate the protective effects of 6-MFA, a fungal-derived immunomodulator, against acrylamide neurotoxicity in rats.
- To explore the potential therapeutic role of 6-MFA in toxic neuropathies.
Main Methods:
- Rats were treated with acrylamide (ACR) and/or 6-MFA.
- Neurotoxic effects, corpus striatal 3H-spiperone binding, and glutathione-S-transferase (GST) activity were assessed.
- Hind limb paralysis was monitored.
Main Results:
- 6-MFA administration significantly protected rats from ACR-induced neurotoxicity.
- ACR increased 3H-spiperone binding and decreased GST activity, which were restored by 6-MFA.
- 6-MFA prevented the development of hind limb paralysis.
Conclusions:
- 6-MFA demonstrates significant neuroprotective effects against acrylamide toxicity.
- Immune mechanisms and local factors likely mediate 6-MFA's protective and repair-facilitating actions.
- 6-MFA holds potential for treating toxic neuropathies.