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Related Experiment Video

Updated: Jun 29, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Misoprostol vaginal insert compared with dinoprostone vaginal insert: a randomized controlled trial.

Deborah A Wing¹,

¹Department of Obstetrics and Gynecology, University of California, Irvine, Orange, California 92869, USA. mfm@uci.edu

Obstetrics and Gynecology

|October 2, 2008

Summary

The misoprostol vaginal insert 100 and dinoprostone vaginal insert offer similar delivery times, while misoprostol vaginal insert 50 is slower. All three methods show comparable cesarean rates and safety profiles for cervical ripening.

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Last Updated: Jun 29, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Area of Science:

Obstetrics and Gynecology
Pharmacology
Reproductive Medicine

Background:

Cervical ripening is crucial for labor induction in women with unfavorable cervix.
Misoprostol and dinoprostone are commonly used agents for cervical ripening.
Comparing different formulations and dosages is essential for optimizing obstetric outcomes.

Purpose of the Study:

To compare the efficacy and safety of misoprostol vaginal insert (50 mcg and 100 mcg) versus dinoprostone vaginal insert (10 mg) for cervical ripening.
To evaluate the primary outcomes of time to vaginal delivery and cesarean delivery rate.
To assess the safety profiles, including adverse events, of the different agents.

Main Methods:

A randomized controlled trial involving 1,308 women requiring cervical ripening (modified Bishop score ≤4).
Participants were assigned to receive misoprostol vaginal insert 100 mcg (n=428), misoprostol vaginal insert 50 mcg (n=443), or dinoprostone vaginal insert 10 mg (n=436).
Primary endpoints included time to vaginal delivery and cesarean birth rate; safety was evaluated by adverse event frequency.

Main Results:

Median time to vaginal delivery was similar for misoprostol vaginal insert 100 mcg (1,596 min) and dinoprostone vaginal insert (1,650 min) (P=.97).
Misoprostol vaginal insert 50 mcg showed a significantly longer median time to delivery (2,127 min) (P=0.01 vs. dinoprostone).
Cesarean delivery rates were comparable across groups (28.3% for MVI 100, 28.9% for MVI 50, and 27.1% for dinoprostone). Adverse events like hyperstimulation syndrome and nonreassuring fetal heart rate patterns were also similar.

Conclusions:

Misoprostol vaginal insert 100 mcg and dinoprostone vaginal insert provide comparable median times to vaginal delivery.
Misoprostol vaginal insert 50 mcg results in a significantly longer interval to vaginal delivery.
All three agents demonstrated similar rates of cesarean delivery and safety profiles, indicating their suitability for cervical ripening.