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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Chronic myeloid leukemia following chemotherapy with 5'-deoxy-5-fluorouridine for gastric cancer
Motohiro Tsuzuki1, Kousuke Handa, Kiyoko Yamamoto
1Department of Medicine, Fujita Health University, School of Medicine, Toyoake. mtsuzuki@fujita-hu.ac.jp
Abstract:
We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer. A 69-year-old man was diagnosed with the chronic phase of CML. Six years previously, he underwent radical subtotal gastrectomy for gastric cancer, and was subsequently treated with oral anti-metabolite 5'-DFUR as adjuvant chemotherapy for 6 years. He was placed on imatinib therapy, and achieved a major molecular response 10 months after the initiation of therapy. This is the first reported case of therapy-related CML following 5'-DFUR treatment.
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