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Related Concept Videos

Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...
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Metabolic States of the Body: The Postabsorptive State

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Related Experiment Video

Updated: Jun 29, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

Caloric restriction and brain function.

Sophie Gillette-Guyonnet1, Bruno Vellas

  • 1Gérontopôle Toulouse, France. gillette.s@chu-toulouse.fr

Current Opinion in Clinical Nutrition and Metabolic Care
|October 2, 2008
PubMed
Summary
This summary is machine-generated.

Caloric restriction may promote brain aging by reducing inflammation and oxidative stress. Further research is needed to clarify its long-term effects in adults and potential benefits for neurodegenerative diseases.

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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

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Last Updated: Jun 29, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

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Published on: March 22, 2016

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Area of Science:

  • Neuroscience
  • Aging Research
  • Nutritional Science

Background:

  • Animal research indicates specific diets, including caloric restriction, benefit brain function and prevent age-related neuronal damage.
  • Understanding the mechanisms behind caloric restriction's effects on brain health is crucial for potential therapeutic applications.

Purpose of the Study:

  • To investigate the mechanisms by which caloric restriction impacts brain functioning.
  • To explore the potential of caloric restriction in preventing or treating neurodegenerative disorders like Alzheimer's disease.
  • To assess the future role of caloric restriction interventions in adult health.

Main Methods:

  • Review of existing animal and human studies on caloric restriction and brain health.
  • Analysis of proposed molecular and cellular mechanisms.
  • Evaluation of data from randomized controlled trials in humans.

Main Results:

  • Caloric restriction is hypothesized to enhance cognitive function through anti-inflammatory effects, reduced oxidative stress, and promotion of synaptic plasticity.
  • It may prevent beta-amyloid neuropathology in Alzheimer's disease models.
  • Caloric restriction and exercise both enhance neurogenesis, suggesting combined benefits.

Conclusions:

  • Caloric restriction shows promise for promoting healthy brain aging.
  • Human data from randomized controlled trials are limited, with no significant cognitive benefits observed, possibly due to methodological issues.
  • Long-term effects in adults require clarification; further studies on combined interventions like caloric restriction and exercise are recommended.