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Related Experiment Video

Updated: Jun 29, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Sarcopenic obesity: definition, cause and consequences.

Sari Stenholm¹, Tamara B Harris, Taina Rantanen

¹Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225-1233, USA.

Current Opinion in Clinical Nutrition and Metabolic Care

|October 2, 2008

Summary

Older obese individuals with muscle weakness face significant health risks. Focusing on muscle strength, not just mass, is crucial for defining and managing sarcopenic obesity to prevent adverse outcomes.

Related Experiment Videos

Last Updated: Jun 29, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Area of Science:

Geriatric Medicine
Nutritional Science
Exercise Physiology

Background:

Older adults with obesity are at increased risk for adverse health outcomes.
Muscle impairment, characterized by decreased mass or strength, exacerbates these risks.

Purpose of the Study:

To discuss pathways leading to muscle impairment in obese individuals.
To examine the health and disability consequences of combined obesity and muscle impairment.
To evaluate whether muscle mass or muscle weakness is a better definitional parameter for sarcopenic obesity.

Main Methods:

Review of current literature on sarcopenic obesity.
Analysis of factors contributing to muscle impairment in obesity.
Discussion of the relationship between obesity, muscle mass, muscle strength, and adverse outcomes.

Main Results:

Sarcopenic obesity develops through excess energy intake, inactivity, inflammation, insulin resistance, and hormonal changes.
Muscle weakness in aging is primarily due to changes in muscle composition and quality, not just mass reduction.
Obesity combined with muscle strength, rather than mass, better predicts risks like functional limitation and mortality.

Conclusions:

Clinicians must identify obese patients with co-existing muscle problems.
Further research is needed to develop targeted prevention and treatment strategies.
Revisiting the definition of sarcopenic obesity to emphasize muscle strength is recommended.