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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Published on: December 19, 2019

Selenium and anticarcinogenesis: underlying mechanisms.

Matthew I Jackson1, Gerald F Combs

  • 1Grand Forks Human Nutrition Research Center, USDA-ARS, Grand Forks, North Dakota 58202-9034, USA.

Current Opinion in Clinical Nutrition and Metabolic Care
|October 2, 2008
PubMed
Summary
This summary is machine-generated.

Selenium compounds exhibit anticarcinogenic effects through various mechanisms, including influencing gene expression and cell cycle regulation. Key selenium metabolites like methylselenol mediate these protective actions against cancer.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Selenium is an essential trace element with known anticancer properties.
  • Understanding the precise mechanisms of selenium's anticarcinogenic action is crucial for its therapeutic application.

Purpose of the Study:

  • To review recent research on the anticarcinogenic mechanisms of selenium.
  • To correlate these effects with the chemical and biochemical functions of selenium species.

Main Methods:

  • Review of recent scientific literature on selenium and cancer.
  • Analysis of studies investigating selenium's effects on cellular processes.
  • Examination of the roles of key selenium metabolites.

Main Results:

  • Selenium compounds impact gene expression, DNA repair, cell signaling, cell cycle regulation, apoptosis, metastasis, and angiogenesis.
  • Anticancer effects are linked to reactive oxygen species production, protein-thiol modification, and methionine mimicry.
  • Key selenium metabolites include hydrogen selenide, methylselenol, and selenomethionine.
  • Selenoprotein polymorphisms may influence cancer risk by affecting selenium metabolism.

Conclusions:

  • The anticarcinogenic effects of selenium involve intermediate mechanisms.
  • Redox cycling, protein-thiol modification, and methionine mimicry are key underlying biochemical processes.
  • Metabolism and disposition pathways of selenium compounds influence their efficacy.