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Updated: Jun 29, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis
1Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, New York, NY 10591, USA. Gavin.Thurston@regeneron.com
British Journal of Cancer
|October 2, 2008
Summary
Tumour angiogenesis therapies targeting VEGF are limited. The Delta-Notch pathway, specifically Delta-like 4 (Dll4), offers a new target. Understanding VEGF and Delta-Notch pathway interactions is crucial for novel antitumour strategies.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Tumour angiogenesis is a key target for cancer therapy, with current treatments focusing on the Vascular Endothelial Growth Factor (VEGF) pathway.
- VEGF pathway inhibitors show limited efficacy, as not all tumors respond, and resistance can develop, necessitating exploration of alternative angiogenesis pathways.
- The Delta-Notch pathway, particularly the ligand Delta-like 4 (Dll4), has emerged as a promising new target in tumour angiogenesis.
Purpose of the Study:
- To review the interactions between the VEGF and Delta-Notch signalling pathways in the context of tumour angiogenesis.
- To highlight the complementary roles of VEGF and Delta-Notch in regulating angiogenesis.
- To provide insights into potential novel therapeutic strategies targeting these pathways.
Main Methods:
- Literature review of existing research on VEGF and Delta-Notch signalling in angiogenesis.
- Analysis of the interplay between these two pathways in tumour development.
- Synthesis of current understanding regarding their interaction mechanisms.
Main Results:
- VEGF acts as a primary stimulus for initiating angiogenesis.
- The Delta-Notch pathway, mediated by Dll4, plays a critical role in guiding cell fate decisions and shaping the angiogenic process.
- The interaction between VEGF and Delta-Notch pathways is complex and essential for effective angiogenesis.
Conclusions:
- The combination of targeting VEGF and Delta-Notch pathways may offer more effective antitumour therapies.
- Understanding the intricate crosstalk between VEGF and Delta-Notch is vital for developing next-generation anti-angiogenic treatments.
- Further research into Dll4 and its interactions could unlock new therapeutic avenues for resistant or non-responsive tumours.
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