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Updated: Jun 29, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Sirtuins--novel therapeutic targets to treat age-associated diseases

Siva Lavu1, Olivier Boss, Peter J Elliott

  • 1Sirtris Pharmaceuticals, Cambridge, Massachusetts 02139, USA.

Nature Reviews. Drug Discovery
|October 2, 2008
PubMed

Insights

Sirtuins are enzymes crucial for aging diseases. Small molecules targeting sirtuins show promise for treating metabolic, neurodegenerative, and inflammatory conditions, offering new therapeutic avenues.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Sirtuins regulate protein acetylation, impacting cellular processes relevant to aging.
  • Dysregulation of sirtuin activity is linked to age-associated diseases.
  • Small-molecule sirtuin modulators are emerging as potential therapeutics.

Purpose of the Study:

  • To review current knowledge on sirtuins as druggable targets.
  • To highlight the therapeutic potential of sirtuin modulation in age-related diseases.
  • To discuss the activation of SIRT1 for type 2 diabetes treatment.

Main Methods:

  • Literature review of sirtuin research.
  • Analysis of preclinical data for sirtuin modulators.
  • Discussion of sirtuin's role in disease pathophysiology.

Main Results:

  • Sirtuins are validated druggable targets.
  • Small-molecule modulators demonstrate efficacy in preclinical models.
  • Sirtuin activation shows promise for treating metabolic diseases like type 2 diabetes.

Conclusions:

  • Sirtuins represent a promising class of enzymes for drug discovery.
  • Targeting sirtuins offers therapeutic potential for multiple age-associated diseases.
  • Further research into sirtuin modulators could lead to novel treatments.

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