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Updated: Jun 29, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Corneal keloid.

M Vanathi¹, Anita Panda, Sanjay Kai

¹From the Cornea Services and Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

The Ocular Surface

|October 2, 2008

Summary

This summary is machine-generated.

Corneal keloids are rare growths on the eye, often linked to injury or congenital conditions. This review details their causes, appearance, and treatment options for better understanding and management.

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Area of Science:

Ophthalmology
Pathology

Background:

Corneal keloids are rare, with fewer than 80 cases reported since 1865.
They can be congenital or acquired, frequently resulting from ocular surface injury or pathology.
Associated congenital conditions include Lowe's syndrome.

Purpose of the Study:

To review and tabulate features of reported corneal keloid cases.
To describe etiologic, clinical, and histopathologic characteristics.
To discuss potential mechanisms of corneal keloid formation.

Main Methods:

Literature review of published corneal keloid cases.
Tabulation of case features including etiology, clinical presentation, and histopathology.
Analysis of reported characteristics to identify patterns and potential formation mechanisms.

Main Results:

Corneal keloids exhibit a haphazard arrangement of fibroblasts, collagen, and blood vessels histopathologically.
They can be distinguished from hypertrophic scars by their delayed onset and progressive enlargement.
The underlying cornea may remain clear or become opaque depending on the keloid's primary pathology.

Conclusions:

Corneal keloids are distinct entities requiring careful diagnosis and management.
Understanding their characteristics aids in differentiating them from other corneal pathologies.
Further research into formation mechanisms may guide future treatment strategies.