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Related Experiment Videos

Reversible symptomatic biliary obstruction associated with ceftriaxone pseudolithiasis.

J Zinberg1, R Chernaik, E Coman

  • 1Gastrointestinal Division, Montefiore Medical Center, Bronx, New York.

The American Journal of Gastroenterology
|September 1, 1991
PubMed
Summary

Ceftriaxone can cause reversible gallbladder sludge or stones. This case report details the first instance of biliary obstruction and pancreatitis linked to ceftriaxone-induced pseudolithiasis.

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Hepatology

Background:

  • Ceftriaxone, a third-generation cephalosporin antibiotic, is widely used for bacterial infections.
  • Ceftriaxone is known to cause gallbladder pseudolithiasis (sludge or stones).
  • These precipitates are typically reversible upon drug cessation and can mimic cholecystitis.

Observation:

  • This study reports a rare complication of ceftriaxone therapy.
  • The patient developed biliary obstruction and secondary pancreatitis.
  • These conditions were associated with reversible ceftriaxone-induced pseudolithiasis.

Findings:

  • This is the first reported case of biliary obstruction and pancreatitis due to ceftriaxone-induced pseudolithiasis.
  • The pseudolithiasis and associated complications were reversible after discontinuing ceftriaxone.

Related Experiment Videos

  • The findings highlight a potential severe adverse effect of ceftriaxone.

    • Implications:

    • Clinicians should be aware of the potential for ceftriaxone to cause biliary obstruction and pancreatitis.
    • Early recognition and drug discontinuation may prevent severe complications.
    • Further research may be warranted to understand the mechanism and incidence of this adverse event.