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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Nutritional assessment and medical dietary therapy for management of obesity in patients with non-dialysis chronic kidney disease: a practical guide for endocrinologist, nutritionists and nephrologists. A consensus statement from the Italian society of endocrinology (SIE), working group of the club nutrition-hormones and metabolism; the Italian society of nutraceuticals (SINut), club ketodiets and nutraceuticals "KetoNut-SINut"; and the Italian society of nephrology (SIN).

Journal of endocrinological investigation·2024
Same author

[The low-protein diet in chronic kidney disease: still a valid prescription?].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2008
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[Low-protein dietary therapy in patients with chronic kidney disease].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2008
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[Compliance with low-protein diet in patients with chronic kidney disease].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2008
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[Low-protein diet in Italy today: the conclusions of the Working Group from the Italian Society of Nephrology].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2008
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Prevalence and correlates of anemia and uncontrolled anemia in chronic hemodialysis patients--the Campania Dialysis Registry.

The International journal of artificial organs·2007

Related Experiment Video

Updated: Jun 29, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

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[Prevalence of chronic kidney disease].

V Bellizzi1

  • 1Unità Operativa di Nefrologia e Dialisi, Ospedale A. Landolfi, Via Melito 5, Solofra, Avellino, Italy. vincenzo.bellizzi@tin.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|October 2, 2008
PubMed
Summary

The prevalence of chronic kidney disease (CKD) is underestimated, particularly stage 3 CKD, a critical stage for complications. Many patients with progressive kidney disease remain undiagnosed and untreated globally and in Italy.

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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

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Last Updated: Jun 29, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

  • Nephrology
  • Epidemiology
  • Public Health

Context:

  • Chronic kidney disease (CKD) prevalence, especially early stages, remains uncertain.
  • CKD stage 3 is a critical juncture for cardiovascular and other major complications.
  • NANHES data indicate a rise in CKD stage 3 prevalence to 7.7% by 2004.

Purpose:

  • To highlight the underdiagnosis of chronic kidney disease and renal failure worldwide.
  • To estimate the prevalence of CKD stages 3-5 in Italy and assess current nephrology clinic follow-up rates.

Summary:

  • CKD and renal failure are significantly underdiagnosed globally.
  • In Italy, approximately 4 million individuals have CKD stages 3-5.
  • Less than 30% of these patients receive care at nephrology clinics, indicating a substantial gap in management.

Impact:

  • The findings underscore a critical gap in CKD diagnosis and management, particularly in Italy.
  • A large number of individuals with potentially progressive kidney disease are not receiving specialist care.
  • This highlights the need for improved screening, diagnosis, and access to nephrology services to prevent complications and disease progression.