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Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations
Dimitrios Vassilopoulos1, Leonard H Calabrese
1Athens University School of Medicine, 2nd Department of Medicine, Hippokration General Hospital, 114 Vass, Sophias Avenue, 115 27 Athens, Greece.
Arthritis Research & Therapy
|October 3, 2008
Summary
Certain viruses can trigger inflammatory arthritis. This review covers the epidemiology, mechanisms, clinical findings, and treatment of common virus-associated arthropathies for modern rheumatologists.
Area of Science:
- Rheumatology
- Virology
- Immunology
Background:
- Viral infections are increasingly recognized as triggers for various forms of inflammatory arthritis.
- Key viruses implicated include hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), parvovirus B19, human T-cell lymphotropic virus-I (HTLV-I), and alphaviruses.
Purpose of the Study:
- To provide a comprehensive overview of virus-associated arthritides.
- To detail the epidemiology, pathophysiology, clinical presentation, laboratory findings, and therapeutic principles for rheumatologists.
Main Methods:
- Literature review of epidemiological studies.
- Analysis of pathophysiological mechanisms.
- Synthesis of clinical and laboratory diagnostic features.
- Review of current therapeutic strategies.
Main Results:
- Specific viruses are linked to distinct patterns of arthritis.
- Understanding viral triggers aids in accurate diagnosis and targeted treatment.
- Early identification and management are crucial for patient outcomes.
Conclusions:
- Virus-associated arthritides represent a significant diagnostic and therapeutic challenge in rheumatology.
- Knowledge of these conditions is essential for 21st-century rheumatologists.
- Further research into viral pathogenesis and treatment is warranted.
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