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Related Experiment Video

Updated: Jun 29, 2026

A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury
05:53

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Published on: May 7, 2021

Persistent spatial working memory deficits in rats with bilateral cortical microgyria.

R Holly Fitch1, Heather Breslawski, Glenn D Rosen

  • 1Department of Psychology/Behavioral Neuroscience, University of Connecticut, Storrs, CT, 06269, USA. roslyn.h.fitch@uconn.edu.

Behavioral and Brain Functions : BBF
|October 3, 2008
PubMed
Summary

Rats with induced microgyria (MG), a condition mimicking human brain development issues, showed persistent spatial working memory deficits. This suggests neuronal migration disruptions may underlie cognitive impairments like those seen in dyslexia.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cognitive Neuroscience

Background:

  • Cortical neuronal migration anomalies, such as microgyria (MG), are linked to human language and cognitive deficits.
  • Rodent models with induced microgyria exhibit similarities to human dyslexic brains and auditory processing impairments.
  • Working memory deficits are also characteristic of human dyslexic populations, necessitating further investigation in animal models.

Purpose of the Study:

  • To investigate the impact of neonatally induced bilateral cortical microgyria (MG) on working memory in adult male rats.
  • To establish a rodent model for studying the relationship between neuronal migration disruptions and working memory impairments.

Main Methods:

  • A delayed match-to-sample radial water maze task was employed to assess spatial working memory.
  • Rats with induced microgyria (MG, n=8) and sham-operated littermates (n=10) were tested over 60 sessions.

Main Results:

  • All rats demonstrated learning, indicated by a decrease in overall test errors.
  • MG rats exhibited significantly more errors than sham rats, a deficit persisting for 12 weeks.
  • MG rats adopted a similar strategy to shams but with reduced effectiveness, evidenced by higher error rates.

Conclusions:

  • Induced microgyria in rats leads to persistent spatial working memory abnormalities.
  • Disruptions in neocortical neuronal migration are associated with lasting deficits in the spatial working memory system.