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Updated: Jun 29, 2026

Translational Rabbit Model of Chronic Cardiac Pacing
Published on: January 6, 2023
Contemporary pacemakers: what the primary care physician needs to know
Karoly Kaszala1, Jose F Huizar, Kenneth A Ellenbogen
1Medical College of Virginia, PO Box 980053, Richmond, VA 23298-0053, USA. kellenbogen@mcvh-vcu.edu
Abstract:
Pacemaker therapy is most commonly initiated because of symptomatic bradycardia, usually resulting from sinus node disease. Randomized multicenter trials assessing the relative benefits of different pacing modes have made possible an evidence-based approach to the treatment of bradyarrhythmias. During the past several decades, major advances in technology and in our understanding of cardiac pathophysiology have led to the development of new pacing techniques for the treatment of heart failure in the absence of bradycardia. Left ventricular or biventricular pacing may improve symptoms of heart failure and objective measurements of left ventricular systolic dysfunction by resynchronizing cardiac contraction. However, emerging clinical data suggest that long-term right ventricular apical pacing may have harmful effects. As the complexity of cardiac pacing devices continues to grow, physicians need to have a basic understanding of device indications, device function, and common problems encountered by patients with devices in the medical and home environment.
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