Related Experiment Video
Updated: Jun 29, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Dimensions of postpartum psychiatric distress: preliminary evidence for broadening clinical scope
C R Marrs1, R T Durette, D P Ferraro
1Department of Psychology, University of Nevada, Las Vegas, Nevada 89154-5030, United States. mom.lab@unlv.edu
Background:
Perinatal psychiatric disturbances afflict a significant number of women sometimes with tragic consequence. Yet, the range and characteristics of these disturbances are poorly understood. The goals of this research were to characterize a broader range of postpartum psychiatric symptoms and to identify their inherent structure using exploratory factor analysis (EFA).
Methods:
An Internet-based survey with 142 Likert-type questions, covering nine dimensions of postpartum mental health was constructed and posted on women's health websites. Data collected from 215 respondents was analyzed in three steps: (1) inter-item correlations were used to reduce the total number of variables by eliminating items that provided redundant information; (2) an EFA using a principal components extraction and VARIMAX rotation was performed and factors loading with Eigenvalues >1.0 were retained; (3) internal consistency was measured with Cronbach's alpha.
Results:
The 10 factors retained accounted for 58% of the variance and included: mental status (28%), psychoticism/morbid thoughts (6%), generalized anxiety (6%), panic (3%), guilt/self-criticism (3%), compulsive behavior (3%), hyper-vigilance (2%), contentment (2%), negative body-image (2%), and manic behavior (2%). There was strong (>0.8) internal consistency in all but the mania factor (0.6).
Limitations:
The study was retrospective and respondent demographics were homogeneous.
Conclusion:
Postpartum psychiatric disturbances are not limited to depressive symptoms. In the current study, cognitive difficulties, psychotic-morbid thoughts and anxiety symptoms accounted for the preponderance of variance while depressive symptoms did not form a cohesive factor and accounted for minimal variance. These results suggest postpartum screening tools should assess a broader array of symptoms.
Related Concept Videos
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Panic Disorder
Depressive Disorders: MDD and Dysthymia
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
