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C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important

Stephen A Badger1, Chee V Soong, Mark E O'Donnell

  • 1Vascular and Endovascular Surgery Department, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom. StephenBadger@btinternet.com

Journal of Vascular Surgery
|October 3, 2008
PubMed

Insights

C-reactive protein (CRP) levels are higher in patients with abdominal aortic aneurysm (AAA), particularly in larger aneurysms. The CRP gene

Area of Science:

  • Cardiovascular Disease Research
  • Biomarker Analysis
  • Genetics and Aneurysm Formation

Background:

  • C-reactive protein (CRP) is a known marker for cardiovascular disease.
  • Abdominal aortic aneurysm (AAA) is a serious vascular condition.
  • Understanding the relationship between CRP and AAA is crucial for risk assessment.

Purpose of the Study:

  • To investigate the association between C-reactive protein (CRP) serum concentration and abdominal aortic aneurysm (AAA).
  • To determine if the CRP gene is associated with the presence and size of AAA.
  • To explore the correlation between a specific CRP gene single nucleotide polymorphism (SNP) and AAA.

Main Methods:

  • Recruitment of AAA patients and healthy controls.
  • Measurement of serum CRP concentration.
  • Assessment of the CRP gene SNP rs3091244 in participants.
  • Correlation analysis of CRP levels with AAA diameter.

Main Results:

  • Significantly higher CRP concentrations were observed in AAA patients compared to controls.
  • CRP levels showed a positive correlation with AAA size, being highest in large aneurysms.
  • No significant difference in the distribution of the CRP gene SNP rs3091244 was found between cases and controls.
  • CRP serum concentration was not influenced by the assessed CRP gene SNP.

Conclusions:

  • CRP production may be linked to the presence of AAA, especially in advanced stages.
  • The studied functional SNP of the CRP gene does not appear to influence serum CRP concentration.
  • The CRP gene SNP rs3091244 is not associated with AAA formation.
Abstract

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