Pancreatic adenocarcinoma metastatic to the pineal gland

Metastases to the pineal gland are rare and reported cases have consisted primarily of gastrointestinal and lung primary malignancies. Here we present the case of a 66-year-old female with autosomal dominant polycystic kidney and liver disease who was found at autopsy to have an unrecognized infiltrating ductal adenocarcinoma of the pancreas with metastases to the liver, lungs and pineal gland. As far as we are aware, this is the first report of a metastasis of infiltrating ductal adenocarcinoma of the pancreas to the pineal gland.