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Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Platelet function in hypertension

Mohammed El Haouari1, Juan A Rosado

  • 1Département de Biologie, Université Mohamed 1(er), Faculté des Sciences, Oujda 60000, Morocco. elhouarim@yahoo.fr

Blood Cells, Molecules & Diseases
|October 3, 2008
PubMed

Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca(2+) concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca(2+) mobilization and attenuates NO bioavailability. The study of the abnormalities in platelet function in hypertensive patients can lead to the development of new pharmacological strategies to prevent and/or palliate hypertension-derived complications associated to platelet hyperactivity.

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