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Related Concept Videos

What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 29, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Colon cancer: it's CIN or CIMP.

Jean-Pierre Issa1

  • 1University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. jpissa@mdanderson.org

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 3, 2008
PubMed
Summary

Sporadic colon cancer is not one disease but at least three distinct subtypes. This finding impacts colon cancer prevention, screening, and therapeutic strategies.

Area of Science:

  • Oncology
  • Genetics
  • Epigenetics

Background:

  • Sporadic colon cancer has historically been treated as a monolithic entity.
  • Recent advancements necessitate a re-evaluation of its classification.

Discussion:

  • Combined genetic and epigenetic analyses reveal significant molecular heterogeneity within sporadic colon cancer.
  • At least three distinct molecular subsets have been identified.

Key Insights:

  • These subsets exhibit unique clinico-pathologic features.
  • Understanding these subsets is crucial for personalized medicine approaches.
  • Implications for targeted prevention, screening, and therapy are profound.

Outlook:

  • Future research should focus on validating these subsets and developing tailored interventions.

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  • This molecular subtyping promises to revolutionize colon cancer management.
  • Further investigation into the specific drivers and vulnerabilities of each subset is warranted.