Related Experiment Video

Updated: Jun 29, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Atopic dermatitis in premature and term children

B Kvenshagen1, M Jacobsen, R Halvorsen

  • 1Department of Paediatrics, Oestfold Hospital Trust, 1603 Fredrikstad, Norway. bent-kv@online.no

Archives of Disease in Childhood
|October 3, 2008
PubMed

Insights

The prevalence of atopic dermatitis (AD) in children under two years old is 18.6%, with no significant differences observed between premature and term infants. Food allergies affect 15.8% of children with AD, regardless of birth status or delivery method.

Area of Science:

  • Pediatric dermatology
  • Allergy and immunology
  • Neonatal care

Background:

  • Atopic dermatitis (AD) is a common chronic inflammatory skin condition in children.
  • Premature birth and mode of delivery are potential risk factors for developing AD and food allergies.
  • Understanding the prevalence and associated factors of AD is crucial for early intervention and management.

Purpose of the Study:

  • To determine the prevalence of atopic dermatitis (AD) in premature versus term infants.
  • To assess the frequency of food allergy in children diagnosed with AD.
  • To investigate if the mode of delivery (cesarean section vs. vaginal delivery) influences AD prevalence.

Main Methods:

  • A prospective follow-up study involving 609 children (193 premature, 416 term) over two years.
  • Clinical assessment of AD symptoms using the SCORAD index and evaluation for food allergies.
  • Diagnostic tests included skin prick tests, specific IgE measurements, elimination diets, and double-blind placebo-controlled challenges.

Main Results:

  • The overall prevalence of AD at two years was 18.6% (19.9% in premature, 17.9% in term infants).
  • Food allergy was present in 15.8% of children with AD, with similar rates in premature and term infants.
  • AD prevalence was comparable between children delivered via cesarean section (17.5%) and vaginally (19.1%).

Conclusions:

  • The prevalence of AD in the first two years of life is approximately 18.6%, not significantly differing between premature and term children.
  • Food allergies occur in 15.8% of children with AD, with no significant difference based on prematurity.
  • The mode of delivery does not appear to influence the prevalence of atopic dermatitis in early childhood.
Abstract

More Related Videos

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...