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Computed tomographic findings and prognosis in thymic epithelial tumor patients
Satomi Yakushiji1, Ukihide Tateishi, Shunji Nagai
1Divisions of Medical Oncology, National Cancer Center Hospital and Research Institute, Tokyo, Japan.
Objective:
To determine which computed tomographic findings are associated with high-risk thymic epithelial tumors and a poor prognosis.
Methods:
Computed tomographic findings of thymic epithelial neoplasms were retrospectively evaluated in 75 patients diagnosed with thymic tumor between January 1997 and October 2003. We analyzed the correlation of the computed tomographic findings, histological subtype according to the World Health Organization classification, and the prognosis.
Results:
There were 34 with type A approximately B1 tumor and 41 with type B2 approximately C tumor. On multiple regression analysis, vascular obliteration and a blunt sternum-anterior mediastinum angle were more frequent with thymic carcinoma than with thymoma. On multivariate analysis, pleural effusion and mediastinal fat infiltration on initial computed tomography had a significant impact on survival.
Conclusions:
Vascular obliteration and a blunt sternum-anterior mediastinum angle were predictive of thymic carcinoma. Pleural effusion and mediastinal fat infiltration were predictive of a poor prognosis.
