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Decrease in serum protein carbonyl groups concentration and maintained hyperhomocysteinemia in patients undergoing

T Sledzinski1, E Goyke, R T Smolenski

  • 1Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1, 80-241, Gdansk, Poland.

Obesity Surgery
|October 3, 2008
PubMed
Summary
This summary is machine-generated.

Bariatric surgery reduces oxidative protein damage in obese patients, improving metabolic markers. However, it does not lower serum homocysteine, a cardiovascular risk factor, suggesting it

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Area of Science:

  • Endocrinology
  • Metabolic Surgery
  • Oxidative Stress Research

Background:

  • Obesity is linked to increased oxidative stress and reactive oxygen species (ROS) production.
  • Factors contributing to elevated ROS in obesity are not fully understood.
  • Serum homocysteine may increase ROS production.

Purpose of the Study:

  • To evaluate the association between serum homocysteine and protein carbonyl groups (oxidative stress marker) in obese patients.
  • To assess changes in these markers before and after bariatric surgery.

Main Methods:

  • Compared serum protein carbonyl groups and homocysteine in 18 obese patients and 10 healthy controls.
  • Measurements were taken before and 6 months after bariatric surgery.
  • Obesity markers (weight, BMI, HOMA-IR, lipids, leptin, glucose, insulin) were also assessed.

Main Results:

  • Obese patients had 50% higher protein carbonyls than controls; levels normalized post-surgery.
  • Serum homocysteine was elevated in obese patients but unchanged after surgery.
  • Bariatric surgery reduced weight, BMI, HOMA-IR, leptin, triglycerides, LDL/HDL ratio, insulin, and glucose.

Conclusions:

  • Bariatric surgery protects against oxidative protein damage and improves metabolic parameters.
  • Serum homocysteine levels did not decrease post-surgery.
  • Serum homocysteine is not directly associated with oxidative stress in obese patients after bariatric surgery.