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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Related Experiment Video

Updated: Jun 29, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

Early experience with biodegradable implants in pediatric patients.

Andreas F Mavrogenis1, Anastasios D Kanellopoulos, George N Nomikos

  • 1First Department of Orthopaedics, Attikon General University Hospital and Athens University Medical School, Athens Greece 41, Ventouri Street, 15562, Holargos, Athens, Greece. andreasfmavrogenis@yahoo.gr

Clinical Orthopaedics and Related Research
|October 3, 2008
PubMed
Summary

Biodegradable implants made from lactic acid polymers and trimethylene carbonate offer a safe and effective solution for bone reconstruction in pediatric patients. This study shows complete bone healing with no adverse tissue reactions in nine young patients.

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Last Updated: Jun 29, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Area of Science:

  • Orthopedic surgery
  • Biomaterials science
  • Pediatric orthopedics

Background:

  • Congenital malformations, trauma, and tumor excision in children often require complex bone reconstruction.
  • Biodegradable implants offer a potential alternative to permanent hardware, avoiding the need for removal surgeries.
  • Lactic acid-based copolymers are known for their biocompatibility and predictable degradation profiles.

Purpose of the Study:

  • To evaluate the safety and efficacy of biodegradable implants for bone reconstruction in pediatric patients.
  • To assess bone healing and tissue response to biodegradable implants in the upper extremity and hand.
  • To determine the clinical outcomes of using poly-L-lactic-poly-DL-lactic acid and trimethylene carbonate copolymers.

Main Methods:

  • Retrospective study of nine pediatric patients undergoing bone reconstruction.
  • Use of 52 biodegradable implants made from a copolymer of lactic acid stereoisomers and trimethylene carbonate.
  • Minimum follow-up of 7 months (mean 17 months) to assess outcomes.

Main Results:

  • Complete bone healing was achieved in all cases.
  • No local or systemic inflammatory or foreign body reactions were observed.
  • Minor issues included screw breakage during insertion (6) and screw head damage (3), attributed to technique.

Conclusions:

  • Biodegradable copolymers of poly-L-lactic-poly-DL-lactic acid and trimethylene carbonate are safe and effective for pediatric bone reconstruction.
  • These implants facilitate successful bone healing with a favorable tissue response.
  • Surgical technique requires careful attention to minimize implant-related complications.