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[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
New adaptive chiral thiophene ligands for copper-catalyzed asymmetric Henry reaction
Marco Bandini1, Salvatore Cabiddu, Enzo Cadoni
1Dipartimento di Chimica G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy. marco.bandini@unibo.it
Abstract:
A new type of adaptive chiral thiophene-based ligands 3 has been designed and developed. The synthetic flexibility of the thienyl ring allowed for the preparation of polydendate C2-symmetric ligands in good yields, carrying simultaneously "hard" as well as "soft" coordinating atoms (i.e., N, S). The coordination attitude of 3 was then tested in the enantioselective base-free Cu(OAc)(2)-catalyzed addition of nitromethane to aromatic aldehydes, leading to the corresponding beta-nitro alcohols in excellent yields and enantiomeric excesses up to 86%.
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