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Updated: Jun 29, 2026

A General Method for Evaluating Incubation of Sucrose Craving in Rats
Published on: November 4, 2011
Ira Remsen, saccharin, and the linear model
1National Museum of American History, Smithsonian Institution, Washington, DC 20013-7012, USA. warnerd@si.edu
Abstract:
While working in the chemistry laboratory at Johns Hopkins University, Constantin Fahlberg oxidized the 'ortho-sulfamide of benzoic acid' and, by chance, found the result to be incredibly sweet. Several years later, now working on his own, he termed this stuff saccharin, developed methods of making it in quantity, obtained patents on these methods, and went into production. As the industrial and scientific value of saccharin became apparent, Ira Remsen pointed out that the initial work had been done in his laboratory and at his suggestion. The ensuing argument, carried out in the courts of law and public opinion, illustrates the importance of the linear model to scientists who staked their identities on the model of disinterested research but who also craved credit for important practical results.
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