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Related Concept Videos

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...

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Assessment of The Effect of Antidiarrheal Drugs and Plant Extracts on Drosophila melanogaster
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Assessment of The Effect of Antidiarrheal Drugs and Plant Extracts on Drosophila melanogaster

Published on: November 17, 2023

[Drug induced diarrhea].

Isabelle Morard1, Antoine Hadengue

  • 1Service de gastroentérologie et d'hépatologie, HUG, 1211 Geneve 14. isabelle.morard@hcuge.ch

Revue Medicale Suisse
|October 4, 2008
PubMed
Summary
This summary is machine-generated.

Drug-induced diarrhea, a common side effect of medications like antibiotics, can be acute or chronic. Diagnosis involves ruling out other causes and observing symptom resolution after discontinuing the suspected drug.

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Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease
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Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Published on: December 27, 2024

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Last Updated: Jun 29, 2026

Assessment of The Effect of Antidiarrheal Drugs and Plant Extracts on Drosophila melanogaster
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Assessment of The Effect of Antidiarrheal Drugs and Plant Extracts on Drosophila melanogaster

Published on: November 17, 2023

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease
03:25

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Published on: December 27, 2024

Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Diarrhea is a frequent adverse drug event associated with common medications such as antibiotics, laxatives, and non-steroidal anti-inflammatory drugs (NSAIDs).
  • Drug-induced diarrhea can manifest as acute or chronic conditions, stemming from predictable pharmacological actions, immune responses, or genomic factors.

Purpose of the Study:

  • To elucidate the diverse pathophysiological mechanisms underlying drug-induced diarrhea.
  • To describe the range of histopathological findings associated with medication-related diarrhea.
  • To outline diagnostic approaches for identifying drug-induced diarrhea.

Main Methods:

  • Review of existing literature on drug-induced diarrhea.
  • Analysis of pathophysiological pathways including osmotic, secretory, and inflammatory mechanisms.
  • Examination of histopathological findings and diagnostic criteria.

Main Results:

  • Pathophysiological mechanisms include altered transit time, malabsorption, osmotic load, secretory processes, and inflammation.
  • Histopathological findings are often non-specific, encompassing ulcerations, inflammatory or ischemic changes, microscopic colitis, and apoptosis.
  • Diagnosis is challenging, relying on excluding other causes and symptom improvement upon drug withdrawal.

Conclusions:

  • Drug-induced diarrhea results from various mechanisms and presents with non-specific histopathological changes.
  • Accurate diagnosis requires careful consideration of medication history and clinical response to drug cessation.