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Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

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Adjacent thoracic lymph node metastases originating from two separate primary cancers: case report.

Khalid A El-Gendy¹, Gary K Atkin¹, Robert E Brightwell²

¹Department of Surgery, Watford General Hospital, Vicarage Rd, Watford, WD18 0HB, Hertfordshire, UK.

International Seminars in Surgical Oncology : ISSO

|October 4, 2008

Summary

This case report details a rare instance of adjacent thoracic lymph nodes with metastases from both breast cancer and esophageal cancer. The study explores potential mechanisms for this dual metastasis phenomenon.

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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

Area of Science:

Oncology
Pathology
Cancer Metastasis Research

Background:

A 51-year-old woman with a history of bilateral breast cancer underwent surgery for esophageal adenocarcinoma.
The patient presented a unique challenge involving metastatic disease in adjacent lymph nodes.

Purpose of the Study:

To report an unusual case of dual malignancy metastasis in adjacent thoracic lymph nodes.
To discuss potential biological mechanisms contributing to this rare oncological finding.

Main Methods:

Surgical resection of the esophagus (radical gastro-oesophagectomy).
Pathological examination of the resection specimen.
Analysis of lymph node involvement from two distinct primary cancers.

Main Results:

The thoracic lymph nodes adjacent to each other showed metastases from both the primary breast cancer and the esophageal adenocarcinoma.
Confirmation of dual metastatic disease in a single anatomical region.

Conclusions:

This case highlights the complexity of cancer metastasis, even within adjacent lymph nodes.
Potential mechanisms, such as local immune suppression by esophageal carcinoma, are considered.
Further research into the microenvironment of lymph node metastasis is warranted.