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IgM multiple myeloma presenting with spinal cord compression caused by a plasmacytoma: A case report
Ihssan Tahan1, Jim Seale, David Edwards
1Bone marrow transplant unit, Bristol Royal Hospital for Children, Upper maudlin street, Bristol, BS2 8BJ, UK. itahan2000@yahoo.com.
Cases Journal
|October 4, 2008
Summary
IgM multiple myeloma is rare but can present with plasmacytomas and spinal cord compression. Standard treatments like chemotherapy and radiotherapy are effective for managing this rare condition.
Area of Science:
- Hematology
- Oncology
Background:
- IgM multiple myeloma is a rare plasma cell disorder.
- It shares clinical, laboratory, and radiological features with multiple myeloma and Waldenstrom's macroglobulinaemia.
Purpose of the Study:
- To report a rare case of IgM multiple myeloma presenting with spinal cord compression.
- To highlight the successful management of this rare complication.
Main Methods:
- A case presentation of an 83-year-old female with IgM multiple myeloma.
- Treatment involved localized radiotherapy, melphalan, prednisolone, thalidomide, cyclophosphamide, and dexamethasone.
Main Results:
- The patient presented with spinal cord compression due to plasmacytomas.
- Initial treatment led to partial remission, followed by disease progression.
- Subsequent treatment controlled the disease for one year.
Conclusions:
- IgM multiple myeloma rarely presents with plasmacytomas, and spinal cord compression is extremely rare.
- Standard treatments for multiple myeloma, including chemotherapy and radiotherapy, are effective.
