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Related Concept Videos

Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Propagation of Action Potentials01:23

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...

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Related Experiment Video

Updated: Jun 29, 2026

A Procedure for Implanting Organized Arrays of Microwires for Single-unit Recordings in Awake, Behaving Animals
10:58

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Published on: February 14, 2014

Deterministic dynamics in neuronal discharge from pallidotomy targets.

W Li1, D Jia, J-L Wang

  • 1Institute of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.

The Journal of International Medical Research
|October 4, 2008
PubMed
Summary

Researchers analyzed neuron firing patterns in Parkinson's disease patients undergoing surgery. Deterministic dynamics were found in the internal globus pallidus (GPi) neuron discharges, offering insights into neurological disorders.

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Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
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Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Area of Science:

  • Neuroscience
  • Neurology
  • Dynamical Systems

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor control.
  • The internal globus pallidus (GPi) plays a crucial role in motor circuitry.
  • Understanding neuronal firing patterns is key to developing effective treatments.

Purpose of the Study:

  • To investigate the non-linear dynamic specificity of neuronal firing patterns in the GPi.
  • To explore the potential of these dynamics for peri-operative targeting in PD surgery.
  • To establish a basis for studying neuronal discharges in other neurological conditions.

Main Methods:

  • Recording spontaneous neuronal firing from GPi using microelectrodes during posteroventral pallidotomy.
  • Processing raw data to extract spiking events and measure interspike intervals.
  • Applying the unstable periodic orbits extraction method to identify periodic orbits in firing patterns.

Main Results:

  • Significant period-1, -2, and -3 orbits were identified in GPi burst firing in all eight PD patients.
  • Evidence of deterministic dynamics in the timing of neuronal discharges was found.
  • The method proved useful for peri-operative targeting during posteroventral pallidotomy.

Conclusions:

  • Deterministic dynamics exist in the timing of GPi neuronal discharges in Parkinson's disease patients.
  • The employed method offers a valuable tool for peri-operative targeting in PD.
  • This approach shows promise for investigating neuronal discharges in other brain regions and neurological disorders.