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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

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Related Experiment Video

Updated: Jun 29, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Chemokines and bone remodeling.

E Galliera, M Locati, A Mantovani

    International Journal of Immunopathology and Pharmacology
    |October 4, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Bone remodeling relies on immune system factors like chemokines. Understanding these inflammatory mediators offers new therapeutic strategies for bone diseases such as osteoporosis and rheumatoid arthritis.

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    Osteoclast Derivation from Mouse Bone Marrow
    06:17

    Osteoclast Derivation from Mouse Bone Marrow

    Published on: November 6, 2014

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    Last Updated: Jun 29, 2026

    A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
    11:47

    A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

    Published on: June 8, 2014

    Osteoclast Derivation from Mouse Bone Marrow
    06:17

    Osteoclast Derivation from Mouse Bone Marrow

    Published on: November 6, 2014

    Area of Science:

    • Osteoimmunology
    • Skeletal biology
    • Immunology

    Background:

    • Bone remodeling, crucial for skeletal health, involves coupled bone resorption and formation.
    • Imbalances in bone remodeling are linked to metabolic bone disorders like osteoporosis and rheumatoid arthritis.
    • Both local and systemic factors, including immune system molecules, regulate bone remodeling.

    Discussion:

    • Osteoimmunology explores the intricate relationship between the skeletal and immune systems.
    • Inflammatory mediators, particularly cytokines and chemokines, play significant roles in bone remodeling.
    • Chemokines are implicated in both physiological bone maintenance and pathological conditions such as rheumatoid arthritis and osteoporosis.

    Key Insights:

    • The immune system's influence on bone remodeling is substantial.
    • Chemokines are key players in the inflammatory processes affecting bone.
    • Targeting common inflammatory mediators presents a promising therapeutic avenue.

    Outlook:

    • Further research into osteoimmunology can uncover novel treatment strategies.
    • Developing therapies that target shared inflammatory pathways may address multiple diseases.
    • Understanding chemokine functions can lead to innovative treatments for skeletal and immune disorders.