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Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

Published on: August 30, 2013

Single reading with computer-aided detection for screening mammography.

Fiona J Gilbert¹, Susan M Astley, Maureen G C Gillan

¹Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom. f.j.gilbert@abdn.ac.uk

The New England Journal of Medicine

|October 4, 2008

Summary

This summary is machine-generated.

Single reading with computer-aided detection (CAD) offers comparable breast cancer detection rates to double reading. This approach could enhance cancer detection from screening mammograms when read by a single expert.

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Area of Science:

Radiology
Oncology
Medical Imaging

Background:

Screening mammography sensitivity for detecting small breast cancers is higher with two readers.
A trial was conducted to compare single-reader performance with computer-aided detection (CAD) against double-reader performance.

Purpose of the Study:

To determine if single-reader performance using CAD matches double-reader performance in breast cancer detection.

Main Methods:

An equivalence trial design with matched-pair comparisons.
31,057 women were randomized to double reading, single reading with CAD, or both.
Primary outcomes included cancer detection rates and recall rates.

Main Results:

Cancer detection proportions were similar: 87.7% for double reading vs. 87.2% for single reading with CAD (P=0.89).
Recall rates were slightly higher for single reading with CAD (3.9%) compared to double reading (3.4%).
Sensitivity, specificity, and positive predictive values were comparable between the two methods.

Conclusions:

Single reading with CAD is a viable alternative to double reading for screening mammography.
This method has the potential to improve breast cancer detection rates when mammograms are interpreted by a single reader.